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ID: ALA1142824
Journal: Bioorg Med Chem Lett
Title: Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist.
Authors: Nakajima Y, Hamashima H, Washizuka K, Tomishima Y, Ohtake H, Imamura E, Miura T, Kayakiri H, Kato M.
Abstract: The discovery of a novel, potent and selective beta(3)-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good beta(3)-AR activity and selectivity, was identified and pharmacokinetics were investigated.
CiteXplore: 15603933