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Basic Information

ID: ALA1142824

Journal: Bioorg Med Chem Lett

Title: Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist.

Authors: Nakajima Y, Hamashima H, Washizuka K, Tomishima Y, Ohtake H, Imamura E, Miura T, Kayakiri H, Kato M.

Abstract: The discovery of a novel, potent and selective beta(3)-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good beta(3)-AR activity and selectivity, was identified and pharmacokinetics were investigated.

CiteXplore: 15603933

DOI: 10.1016/j.bmcl.2004.11.001