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ID: ALA1142857
Journal: Bioorg Med Chem Lett
Title: A new class of high affinity thyromimetics containing a phenyl-naphthylene core.
Authors: Hangeland JJ, Friends TJ, Doweyko AM, Mellström K, Sandberg J, Grynfarb M, Ryono DE.
Abstract: High affinity thyromimetics containing a novel phenyl-naphthylene core are reported. The functionalized core is readily accessible via a Suzuki coupling protocol. Examples of this new class of TR ligands have sub-nanomolar binding affinities for the TRbeta receptor and low to modest selectivity for TRbeta. They also exhibit an SAR that diverges from other thyromimetics that are based on the diaryl ether core found in 3,5,3'-triiodothyronine.
CiteXplore: 16099653