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ID: ALA1142879
Journal: Eur J Med Chem
Title: Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases.
Authors: Brault L, Denancé M, Banaszak E, El Maadidi S, Battaglia E, Bagrel D, Samadi M.
Abstract: An efficient synthesis of dialkylsubstituted maleic anhydrides 1a-j is described. The inhibitory potential of these original anhydride derivatives was tested toward the three human isoforms A, B and C of dual specific phosphatases Cdc25. A micromolar range inhibition of Cdc25s was observed with the maleic anhydrides bearing simple alkyl side chains longer than C(9), to reach the optimal activity with a C(17) chain length.
CiteXplore: 17084000