Document Report Card
Basic Information
ID: ALA1143024
Journal: Bioorg Med Chem
Title: Clavaminols A-F, novel cytotoxic 2-amino-3-alkanols from the ascidian Clavelina phlegraea.
Authors: Aiello A, Fattorusso E, Giordano A, Menna M, Navarrete C, Muñoz E.
Abstract: The chemical investigation of the Mediterranean ascidian Clavelina phlegraea has led to the isolation of six new 2-amino-3-alkanol derivatives, clavaminols A-F (1-6). Their stereostructures were established by analysis of spectroscopic data and chemical conversion. Clavaminols A, B, C, and F were tested for their cytotoxic and pro-apoptotic properties and clavaminol A was shown to be the more potent cytotoxic compound of this series inducing cell death through activation of the apoptotic machinery.
CiteXplore: 17336534