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ID: ALA1143091
Journal: Bioorg Med Chem Lett
Title: Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents.
Authors: Liu P, Zhu S, Li P, Xie W, Jin Y, Sun Q, Wu Q, Sun P, Zhang Y, Yang X, Jiang Y, Zhang D.
Abstract: A series of 1-(substituted biaryloxy)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol were synthesized and their antifungal activities were evaluated against eight human pathogenic fungi in vitro. Seventeen compounds showed activity 4- to 64-fold higher than voriconazole against Candida albicans. SAR clearly suggested that introduction of a biaryloxy side chain greatly enhanced the antifungal activity of triazole analogs against Candida species.
CiteXplore: 18467095