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ID: ALA1143138
Journal: Bioorg Med Chem Lett
Title: Synthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole.
Authors: Vatmurge NS, Hazra BG, Pore VS, Shirazi F, Chavan PS, Deshpande MV.
Abstract: Synthesis of novel 1,2,3-triazole-linked beta-lactam-bile acid conjugates 17-24 using 1,3-dipolar cycloaddition reaction of azido beta-lactam and terminal alkyne of bile acids in the presence of Cu(I) catalyst (click chemistry) have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and moderate antibacterial activity against all the tested strains.
CiteXplore: 18267360