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ID: ALA1143184
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of a fluorescent muscarinic antagonist.
Authors: Jones LH, Randall A, Napier C, Trevethick M, Sreckovic S, Watson J.
Abstract: The design and concise synthesis of a fluorescent tolterodine-BODIPY (boron dipyrromethene) conjugate is described which possesses potent antimuscarinic activity. This derivative illustrates proof-of-concept for the preparation of other useful fluorophoric antimuscarinic agents which have potential utility in receptor occupancy studies and high throughput screens.
CiteXplore: 18042383