Basic Information
ID: ALA1143191
Journal: Bioorg Med Chem Lett
Title: The synthesis and biological evaluation of a range of novel functionalized benzopyrans as potential potassium channel activators.
Authors: Tyrrell E, Tesfa KH, Greenwood I, Mann A.
Abstract: A range of novel benzopyrans have been synthesised and biologically evaluated for K(ATP) channel activity employing cromakalim 1 as a benchmark K(ATP) channel opener. Although the compounds that were evaluated demonstrated a reduced ability to relax phenylephrine stimulated rat thoracic tissue, we provide evidence that benzopyrans 7a-h may be operating via an alternative mechanism than ATP-sensitive K(+) channel activity.
CiteXplore: 18191566
DOI: 10.1016/j.bmcl.2007.11.135
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets