Document Report Card
Basic Information
ID: ALA1143241
Journal: Bioorg Med Chem Lett
Title: Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity.
Authors: Zhao Z, Robinson RG, Barnett SF, Defeo-Jones D, Jones RE, Hartman GD, Huber HE, Duggan ME, Lindsley CW.
Abstract: This letter describes the development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved aqueous solubility (approximately 18 mg/mL) that translates into enhanced cell activity and caspase-3 induction.
CiteXplore: 18054229