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ID: ALA1143248
Journal: Bioorg Med Chem Lett
Title: Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation.
Authors: Douglass JG, deCamp JB, Fulcher EH, Jones W, Mahanty S, Morgan A, Smirnov D, Boyer JL, Watson PS.
Abstract: Modified adenosine derivatives may lead to the development of P2Y(12) antagonists that are potent, selective, and bind reversibly to the receptor. Analogues of 2',3'-trans-styryl acetal-N6-ureido-adenosine monophosphate were prepared by modification of the 5'-position. The resulting analogues were tested for P2Y(12) antagonism in a platelet aggregation assay.
CiteXplore: 18276138