Document Report Card

ID: ALA1143253

Journal: J Med Chem

Title: Strongylophorines: natural product inhibitors of hypoxia-inducible factor-1 transcriptional pathway.

Authors: Mohammed KA, Jadulco RC, Bugni TS, Harper MK, Sturdy M, Ireland CM.

Abstract: Rapidly increasing experimental and clinical data provides evidence for the role of hypoxia inducible factor-1 (HIF-1) as a crucial mediator of tumor survival and progression. In our effort to identify inhibitors of the HIF-1 activation pathway, we screened fractions from marine invertebrates. Fractions from an extract of Petrosia (Strongylophora) strongylata potently inhibited the HIF-1 activation pathway. Strongylophorines 2, 3, and 8 isolated from the active fractions were found to be responsible for the HIF-1 inhibition with EC 50 values of 8, 13, and 6 microM, respectively.

CiteXplore: 18278856

DOI: 10.1021/jm7010854