Basic Information
ID: ALA1143262
Journal: Bioorg Med Chem Lett
Title: 1-Oxo-3-substitute-isothiochroman-4-carboxylic acid compounds: synthesis and biological activities of FAS inhibition.
Authors: Wang X, Zhao G, Chen Y, Xu X, Zhong W, Wang L, Li S.
Abstract: A new series 1-oxo-3-substitute-isothiochroman-4-carboxylic acid compounds have been designed and synthesized. Screening of these molecules for FAS inhibition in vitro has indicated that compounds 2c and 2d showed more effective FAS inhibition activities and higher therapeutic index than C75.
CiteXplore: 19097781
DOI: 10.1016/j.bmcl.2008.12.010
Patent ID: ┄
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