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ID: ALA1143302
Journal: Bioorg Med Chem Lett
Title: Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase.
Authors: Scott DA, Balliet CL, Cook DJ, Davies AM, Gero TW, Omer CA, Poondru S, Theoclitou ME, Tyurin B, Zinda MJ.
Abstract: 3-amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modifications at the quinoline 6- and 7-positions.
CiteXplore: 19112018