Document Report Card

ID: ALA1143385

Journal: J Med Chem

Title: The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.

Authors: Wroblowski B, Wigglesworth MJ, Szekeres PG, Smith GD, Rahman SS, Nicholson NH, Muir AI, Hall A, Heer JP, Garland SL, Coates WJ.

Abstract: The novel 7-transmembrane receptor MrgX1 is located predominantly in the dorsal root ganglion and has consequently been implicated in the perception of pain. Here we describe the discovery and optimization of a small molecule agonist and initial docking studies of this ligand into the receptor in order to provide a suitable lead and tool compound for the elucidation of the physiological function of the receptor.

CiteXplore: 19146417

DOI: 10.1021/jm800962k