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ID: ALA1143434
Journal: Bioorg Med Chem Lett
Title: A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.
Authors: Choong IC, Serafimova I, Fan J, Stockett D, Chan E, Cheeti S, Lu Y, Fahr B, Pham P, Arkin MR, Walker DH, Hoch U.
Abstract: The identification of a selective CDK2, 7, 9 inhibitor 4 with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice.
CiteXplore: 18842409