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ID: ALA1143439
Journal: Bioorg Med Chem Lett
Title: Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons.
Authors: Zieminska E, Lazarewicz JW, Couladouros EA, Moutsos VI, Pitsinos EN.
Abstract: Constraining the catechol aryl ether moiety of bastadins by incorporation into a macrocyle is not necessary in order to mimic the effects of these marine natural products on neuronal calcium homeostasis. Simple, acyclic analogs that embody the 'western' or 'eastern' parts of bastadins were found to evoke comparable responses with bastadin 5.
CiteXplore: 18851910