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ID: ALA1143458
Journal: Bioorg Med Chem Lett
Title: An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential.
Authors: Dixon MJ, Andersen OA, van Aalten DM, Eggleston IM.
Abstract: The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.
CiteXplore: 16153835