The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides.

ID: ALA1143486

Journal: Bioorg Med Chem Lett

Title: The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides.

Authors: Wang X, Migawa MT, Sannes-Lowery KA, Swayze EE.

Abstract: The first carbohydrate-free aminoglycoside analogs bearing the 2-deoxystreptamine moiety were synthesized from asymmetrically protected 2-deoxystrepamine and subsequently demonstrated to have significant binding to the 16S A-site rRNA target and moderate functional activity.

CiteXplore: 16168642

DOI: 10.1016/j.bmcl.2005.08.027

Patent ID: ┄