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ID: ALA1143524
Journal: Bioorg Med Chem Lett
Title: Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens.
Authors: Son KH, Oh HM, Choi SK, Han DC, Kwon BM.
Abstract: A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6alpha-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI(50) 2-5 microg/mL.
CiteXplore: 15808460