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ID: ALA1143550
Journal: Bioorg Med Chem Lett
Title: A structural screening approach to ketoamide-based inhibitors of cathepsin K.
Authors: Barrett DG, Catalano JG, Deaton DN, Long ST, McFadyen RB, Miller AB, Miller LR, Wells-Knecht KJ, Wright LL.
Abstract: Several novel ketoamide-based inhibitors of cathepsin K have been identified. Starting from a modestly potent inhibitor, structural screening of P2 elements led to 100-fold enhancements in inhibitory activity. Modifications to one of these leads resulted in an orally bioavailable cathepsin K inhibitor.
CiteXplore: 15837295