Document Report Card

ID: ALA1143560

Journal: J Med Chem

Title: Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.

Authors: McBriar MD, Guzik H, Xu R, Paruchova J, Li S, Palani A, Clader JW, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar B, Weig B.

Abstract: Melanin concentrating hormone (MCH) is involved in regulation of food intake and energy homeostasis. Antagonists of the MCH receptor are expected to affect food intake and weight gain, making MCH-R1 an attractive target for obesity treatment. Herein, we report the discovery of a novel, orally active series of MCH-R1 antagonists that exhibit in vivo efficacy in rodent obesity models.

CiteXplore: 15801820

DOI: 10.1021/jm049035q