Document Report Card

ID: ALA1143619

Journal: J Med Chem

Title: Synthesis and biological evaluation of aminopolyamines.

Authors: Bergeron RJ, Huang G, McManis JS, Yao H, Nguyen JN.

Abstract: Exploitation of the polyamine backbone as a vector for intracellular transport of various pharmacophores has focused largely on fixing the cargo molecule to one of the nitrogens in the linear chain. This communication describes the assembly of a model aminopolyamine analogue, 6-amino-N(1),N(12)-diethylspermine, and its biological properties. This amino polyamine presents an additional site of attachment for cargo molecules, reduces cell growth, and achieves cellular concentrations that are higher than those of N(1),N(12)-diethylspermine.

CiteXplore: 15857111

DOI: 10.1021/jm050024m