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ID: ALA1143657
Journal: Bioorg Med Chem Lett
Title: Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors.
Authors: Jeong TS, Kim KS, Yu H, Kim MJ, Cho KH, Choi YK, Kim HC, Park HY, Lee WS.
Abstract: A series of 2a-i were prepared from a lead compound, saucerneol B (1) for evaluating their acyl-CoA: cholesterol acyltransferase inhibitory activities. Compounds 2a-g exhibited the high specificity of hACAT-1 than hACAT-2, whereas 2h and 2i showed very weak inhibitory activities in both hACAT-1 and hACAT-2. Saucerneol B (1) exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.
CiteXplore: 15603959