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ID: ALA1143712
Journal: Bioorg Med Chem
Title: Structure-activity relationships of novel N-acyloxy-1,4-dihydropyridines as P-glycoprotein inhibitors.
Authors: Voigt B, Coburger C, Monár J, Hilgeroth A.
Abstract: Series of novel N-acyloxy-1,4-dihydropyridines have been synthesized and evaluated as P-glycoprotein inhibitors in an in vitro assay to estimate their potential to act as multidrug resistance modulators in cancer cells. Structure-activity relationships are discussed and prove a significant and regiospecific influence of certain functional groups.
CiteXplore: 17533131