Document Report Card

ID: ALA1143714

Journal: J Nat Prod

Title: Nocardichelins A and B, siderophores from Nocardia strain acta 3026.

Authors: Schneider K, Rose I, Vikineswary S, Jones AL, Goodfellow M, Nicholson G, Beil W, Süssmuth RD, Fiedler HP.

Abstract: An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genus Nocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compounds strongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma with GI50 values in a low micromolar to nanomolar range. The structural characterization of the compounds was performed by mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combine the structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores (desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation, was positive, confirming the role as a siderophore.

CiteXplore: 17536856

DOI: 10.1021/np060612i