Document Report Card

ID: ALA1143819

Journal: Antimicrob Agents Chemother

Title: In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes.

Authors: Tong Z, Widmer F, Sorrell TC, Guse Z, Jolliffe KA, Halliday C, Lee OC, Kong F, Wright LC, Chen SC.

Abstract: The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 microg/ml, respectively. MI was more active than ITC (P < 0.001).

CiteXplore: 17371821

DOI: 10.1128/aac.01382-06