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ID: ALA1143898
Journal: Bioorg Med Chem Lett
Title: Synthesis and study of antiviral and anti-radical properties of aminophenol derivatives.
Authors: Shadyro O, Ksendzova G, Polozov G, Sorokin V, Boreko E, Savinova O, Dubovik B, Bizunok N.
Abstract: A number of sterically-hindered o-aminophenol derivatives have been synthesized, and their antiviral activity in parallel with reactivity towards commonly encountered free-radical intermediates was investigated. Of the compounds tested, the highest activity in suppressing replication of Herpes simplex type l viruses was displayed by N-acyl and N-aryl derivatives of 4,6-di-tert-butyl-2-aminophenol, which were able to interact with organic free radicals and, at the same time, manifested low reactivity towards reactive oxygen species.
CiteXplore: 18334296