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ID: ALA1143901
Journal: Bioorg Med Chem Lett
Title: Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3.
Authors: Hayes ME, Breinlinger EC, Wallace GA, Grongsaard P, Miao W, McPherson MJ, Stoffel RH, Green DW, Roth GP.
Abstract: Modification of a 2-iminobenzimidazole series derived from an HTS hit resulted in compounds with improved in-vitro species selectivity. Incorporation of an 8-quinoline amide and conformational rigidification of an aliphatic tether furnished potent compounds suitable for further lead optimization.
CiteXplore: 18337097