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ID: ALA1143903
Journal: Bioorg Med Chem Lett
Title: Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens.
Authors: Periyasami G, Raghunathan R, Surendiran G, Mathivanan N.
Abstract: A series of novel dispirooxindolopyrrolizidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from proline and isatin with the dipolarophile (E)-2-arylidine-1-keto carbazoles. The synthesized cycloadducts were evaluated for antimicrobial activities. Compounds 7d and 7e showed relatively good antibacterial and antifungal activities.
CiteXplore: 18342506