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ID: ALA1143903

Journal: Bioorg Med Chem Lett

Title: Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens.

Authors: Periyasami G, Raghunathan R, Surendiran G, Mathivanan N.

Abstract: A series of novel dispirooxindolopyrrolizidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from proline and isatin with the dipolarophile (E)-2-arylidine-1-keto carbazoles. The synthesized cycloadducts were evaluated for antimicrobial activities. Compounds 7d and 7e showed relatively good antibacterial and antifungal activities.

CiteXplore: 18342506

DOI: 10.1016/j.bmcl.2008.02.065