Document Report Card
Basic Information
ID: ALA1143922
Journal: Bioorg Med Chem Lett
Title: Pharmacophore identification of Raf-1 kinase inhibitors.
Authors: Zhu T, Jiao Y, Chen YD, Wang X, Li HF, Zhang LY, Lu T.
Abstract: A three-dimensional pharmacophore model was developed based on 25 currently available Raf-1 kinase inhibitors. The best pharmacophore hypothesis (Hypo1), consisting of four chemical features (one hydrogen-bond acceptor, one hydrogen-bond donor, and two hydrophobic groups), has a correlation coefficient of 0.972. The results of our study provide a valuable tool in designing new leads with desired biological activity by virtual screening.
CiteXplore: 18346893