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ID: ALA1143934
Journal: Bioorg Med Chem
Title: Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines.
Authors: Suhara Y, Hirota Y, Nakagawa K, Kamao M, Tsugawa N, Okano T.
Abstract: Novel omega-oxygenated vitamin K(2) analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in gamma-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K(2) analogues for the development of new drugs.
CiteXplore: 18171617