Document Report Card

Basic Information

ID: ALA1143934

Journal: Bioorg Med Chem

Title: Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines.

Authors: Suhara Y, Hirota Y, Nakagawa K, Kamao M, Tsugawa N, Okano T.

Abstract: Novel omega-oxygenated vitamin K(2) analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in gamma-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K(2) analogues for the development of new drugs.

CiteXplore: 18171617

DOI: 10.1016/j.bmc.2007.12.025