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ID: ALA1143938
Journal: Bioorg Med Chem
Title: Synthesis and antiviral activities of novel chiral cyanoacrylate derivatives with (E) configuration.
Authors: Chen Z, Wang X, Song B, Wang H, Bhadury PS, Yan K, Zhang H, Yang S, Jin L, Hu D, Xue W, Zeng S, Wang J.
Abstract: The intermediate 3 is converted by the nucleophilic attack of the appropriate aryl (heterocyclic) amine under microwave irradiation into the chiral (E) isomers of title compound 4. These compounds exhibited weak to good anti-TMV bioactivity with (R)-4p showing significant enhancement of disease resistance in tobacco leaves.
CiteXplore: 18178446