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ID: ALA1143975
Journal: Bioorg Med Chem
Title: Synthesis of novel spirostanic saponins and their cytotoxic activity.
Authors: Hernández JC, León F, Brouard I, Torres F, Rubio S, Quintana J, Estévez F, Bermejo J.
Abstract: This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds.
CiteXplore: 18023191