Basic Information
ID: ALA1143984
Journal: Bioorg Med Chem
Title: Anti-inflammatory activity profile of JANEX-1 in preclinical animal models.
Authors: Uckun FM, Tibbles H, Ozer Z, Qazi S, Vassilev A.
Abstract: We examined the biologic activity of the rationally designed JAK3 inhibitor, JANEX-1, in several cellular and animal models of inflammation. Notably, JANEX-1 exhibited potent anti-inflammatory activity in each of these preclinical models, including mouse models of peritonitis, colitis, cellulitis, and systemic inflammatory response syndrome. Therefore, JANEX-1 may prove useful as a broad-spectrum anti-inflammatory agent. The present study may provide the basis for new and effective treatment as well as prevention programs for inflammatory disorders.
CiteXplore: 18024136
DOI: 10.1016/j.bmc.2007.10.066
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets