Cytotoxic simplified tubulysin analogues.
Basic Information
ID: ALA1144042
Journal: J Med Chem
Title: Cytotoxic simplified tubulysin analogues.
Authors: Raghavan B, Balasubramanian R, Steele JC, Sackett DL, Fecik RA.
Abstract: An efficient route for the synthesis of the tubulysin family of antimitotic peptides was developed. Simplified tubulysin analogues were synthesized to define the minimum pharmacophore required for cytotoxicity. Simplified tubulysin analogues retain significant cytotoxicity and reveal important preliminary structure-activity relationships.
CiteXplore: 18314944
DOI: 10.1021/jm701321p
Patent ID: ┄
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