Document Report Card

ID: ALA1144056

Journal: J Nat Prod

Title: Characterization of 6-epi-3-anhydroophiobolin B from Cochliobolus heterostrophus.

Authors: Shen X, Krasnoff SB, Lu SW, Dunbar CD, O'Neal J, Turgeon BG, Yoder OC, Gibson DM, Hamann MT.

Abstract: The new sesterterpenoid 6-epi-3-anhydroophiobolin B (1) and six known ophiobolins were isolated from the extracts of the fungus Cochliobolus heterostrophus race O. The structure of 6-epi-3-anhydroophiobolin B was deduced from analysis of spectral data and the structural characterization of dehydration and dimerization products. Ophiobolin A (2) showed potent activity in cytotoxicity assays and marginal activity in antimalarial assays.

CiteXplore: 10395513

DOI: 10.1021/np980462e