DNA polymerase beta inhibitors from Sandoricum koetjape.

ID: ALA1144085

Journal: J Nat Prod

Title: DNA polymerase beta inhibitors from Sandoricum koetjape.

Authors: Sun DA, Starck SR, Locke EP, Hecht SM.

Abstract: Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase beta inhibition led to the isolation of three active compounds (1-3) having IC(50) values from 20 to 36 microM. Derivatives 5-14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase beta with IC(50) values ranging from 16 to 36 microM.

CiteXplore: 10479314

DOI: 10.1021/np990104r

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