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ID: ALA1144173
Journal: Bioorg Med Chem Lett
Title: 1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.
Authors: Guo Q, Chandrasekhar J, Ihle D, Wustrow DJ, Chenard BL, Krause JE, Hutchison A, Alderman D, Cheng C, Cortright D, Broom D, Kershaw MT, Simmermacher-Mayer J, Peng Y, Hodgetts KJ.
Abstract: The design, synthesis, and structure-activity studies of a novel series of BK B(1) receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat bradykinin B(1) receptor were discovered.
CiteXplore: 18752949