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ID: ALA1144177
Journal: Bioorg Med Chem Lett
Title: Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors.
Authors: Frohn M, Viswanadhan V, Pickrell AJ, Golden JE, Muller KM, Bürli RW, Biddlecome G, Yoder SC, Rogers N, Dao JH, Hungate R, Allen JR.
Abstract: We report the structure-based design and synthesis of a novel series of aza-benzimidazoles as PHD2 inhibitors. These efforts resulted in compound 22, which displayed highly potent inhibition of PHD2 function in vitro.
CiteXplore: 18755588