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ID: ALA1144202

Journal: Bioorg Med Chem Lett

Title: Triazole oxytocin antagonists: identification of aryl ether replacements for a biaryl substituent.

Authors: Brown A, Brown L, Brown TB, Calabrese A, Ellis D, Puhalo N, Smith CR, Wallace O, Watson L.

Abstract: Several potent aryl ether/triazole oxytocin antagonists are described. The lead compound in this series had significantly improved aqueous solubility over related systems containing a biaryl substituent.

CiteXplore: 18778939

DOI: 10.1016/j.bmcl.2008.08.066