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ID: ALA1144203

Journal: Bioorg Med Chem

Title: Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.

Authors: Gawin R, De Clercq E, Naesens L, Koszytkowska-Stawińska M.

Abstract: The acyclic azanucleosides with 2-, 3-, or 4-aminobenzenesulfonyl function at the nitrogen atom of the sugar mimic were prepared by coupling of 2-, 3-, or 4-nitro-N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)benzenesulfonamide with the silylated pyrimidine nucleobases followed by the reduction of the nitro group with sodium dithionite in aqueous solution or the palladium-catalysed transfer hydrogenation. The azanucleosides were evaluated for, but found to be devoid of, activity against several RNA- and DNA-viruses in vitro.

CiteXplore: 18778942

DOI: 10.1016/j.bmc.2008.08.041