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ID: ALA1144234
Journal: Bioorg Med Chem Lett
Title: Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
Authors: Somsák L, Nagy V, Vidal S, Czifrák K, Berzsényi E, Praly JP.
Abstract: 2-Naphthyl-substituted glucopyranosylidene-spiro-oxathiazole prepared following a novel design principle was found to be the best known glucose analogue inhibitor of rabbit muscle glycogen phosphorylase b (K(i) 160 nM).
CiteXplore: 18793852