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ID: ALA1144246
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1.
Authors: Jolidon S, Alberati D, Dowle A, Fischer H, Hainzl D, Narquizian R, Norcross R, Pinard E.
Abstract: Several novel classes of potent and small amide-type inhibitors of glycine transport (GlyT1) were developed through sequential simplification of a benzodiazepinone-lead structure identified from a high-throughput screening. The most potent compounds of these structurally simple classes show low nanomolar inhibition at the GlyT1 target.
CiteXplore: 18805008