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ID: ALA1144263
Journal: Bioorg Med Chem Lett
Title: Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B.
Authors: Feng S, Xia Y, Han D, Zheng C, He X, Tang X, Bai D.
Abstract: By targeting dual active sites of AChE, a number of new derivatives of HupB have been synthesized and tested as acetylcholinesterase inhibitors. The most potent compound, bis-HupB 5b is 72-fold more potent in AChE inhibition and 79-fold more selective for AChE versus BChE than HupB.
CiteXplore: 15664805