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ID: ALA1144284
Journal: Bioorg Med Chem Lett
Title: Pharmacophore identification of alpha(1A)-adrenoceptor antagonists.
Authors: Li MY, Tsai KC, Xia L.
Abstract: A chemical feature based pharmacophore model was developed for alpha(1A)-adrenoceptor antagonists by HypoGen module implemented in catalyst software package. The best scoring pharmacophore hypothesis, Hypo1, consisted of four important chemical features (one positive ion, one hydrogen-bond donor, one aromatic ring, and one hydrophobic group). The results of our study provide a valuable tool in designing new leads with desired biological activity by virtual screening.
CiteXplore: 15664832