Active site directed inhibitors of replication-specific bacterial DNA polymerases.

Basic Information

ID: ALA1144295

Journal: Bioorg Med Chem Lett

Title: Active site directed inhibitors of replication-specific bacterial DNA polymerases.

Authors: Wright GE, Brown NC, Xu WC, Long ZY, Zhi C, Gambino JJ, Barnes MH, Butler MM.

Abstract: 7-Substituted-N(2)-(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram(+) bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram(-) bacteria.

CiteXplore: 15664846

DOI: 10.1016/j.bmcl.2004.11.016

Patent ID: ┄

Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets