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ID: ALA1144308
Journal: Bioorg Med Chem Lett
Title: Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes.
Authors: Voigt B, Meijer L, Lozach O, Schächtele C, Totzke F, Hilgeroth A.
Abstract: A series of 1-aza-9-oxafluorenes with functionally varied 3-substituents have been prepared from N-phenoxycarbonyl-4-phenyl-1,4-dihydropyridines and p-benzoquinone and biologically evaluated as inhibitors of various cyclin-dependant kinases. The absence of a 3-hydrogen bond acceptor function leads to a complete loss of inhibitory activity. Differing hydrogen bond acceptor functions surprisingly cause significant shifts in the selectivity of inhibition profiles.
CiteXplore: 15664865