Document Report Card
Basic Information
ID: ALA1144320
Journal: Bioorg Med Chem Lett
Title: Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
Authors: Koyama J, Morita I, Kobayashi N, Osakai T, Usuki Y, Taniguchi M.
Abstract: Antimicrobial activities of two azafluorenones, four 1-azaanthraquinones, five 2-azaanthraquinones, and one 2-azaquinone were tested. Several azaanthraquinones possessed broad, potent activity, while the azafluorenones demonstrated weak activity. The following structure-activity relationship was postulated: (1) activity decreased in the order 2-azaanthraquinones>1-azaanthraquinones>azafluorenones; and (2) a hydroxyl group at the peri-carbonyl group enhanced activity. In addition, correlations among reduction potential, hydrophobic parameter, and antimicrobial activity were discussed.
CiteXplore: 15686916