Basic Information
ID: ALA1144323
Journal: Bioorg Med Chem Lett
Title: Reversal of anticancer drug resistance by COTC based on intracellular glutathione and glyoxalase I.
Authors: Kamiya D, Uchihata Y, Ichikawa E, Kato K, Umezawa K.
Abstract: Suppression of resistance to anticancer drugs by COTC of glyoxalase I (GloI) inhibitor targeting intracellular glutathione (GSH) and GloI was studied. Depletion of the cellular GSH content and inhibition of GloI by COTC increased chemotherapy-mediated apoptosis in apoptosis-resistant pancreatic adenocarcinoma AsPC-1 cells.
CiteXplore: 15686923
DOI: 10.1016/j.bmcl.2004.12.031
Patent ID: ┄
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