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ID: ALA1144324

Journal: Bioorg Med Chem Lett

Title: 2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity.

Authors: Jung YS, Joe BY, Cho SJ, Konishi Y.

Abstract: Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 microM of the IC(50) value.

CiteXplore: 15686926

DOI: 10.1016/j.bmcl.2004.12.029